Showing posts with label Genetic Engineering. Show all posts
Showing posts with label Genetic Engineering. Show all posts

Thursday, October 18, 2012

11 January 2011 – The impossibility of data management

Colleagues,

Empirical science has four steps: observation, hypothesis, experimentation and synthesis.  Two of those - observation, which requires noting a previously unexplained phenomenon, and experimentation, which is designed to produce evidence - are based, respectively, on collecting and generating data for further analysis.  Data is the bedrock of the scientific method, because it is only through data that established, often cherished, assumptions about how the world works may legitimately be challenged.  So you’d think there couldn’t be any such thing as ‘too much’ data, right?

“Wrong,” says David Weinberger.  In a new book with the wonderfully expressive title Too Big to Know: Rethinking Knowledge Now That the Facts Aren’t the Facts, Experts are Everywhere, and the Smartest Person in the Room is the Room, Weinberger argues that our ability to generate data is outstripping not only our ability to organize it in such a way that we can draw useful conclusions from it, but even our cognitive ability to grasp the complexities of the phenomena we are trying to understand.

This isn’t a new phenomenon.  As Weinberger notes, in 1963 - right around the same time that Edward Lorenz formulated chaos theory to explain the inherent impossibility of predicting the long-term behaviour of non-linear systems like weather - Bernard Forscher of the Mayo Clinic published a letter in Science entitled “Chaos in the Brickyard”, in which he complained that scientists were generating - of all things - too many facts.  According to Weinberger,

...the letter warned that the new generation of scientists was too busy churning out bricks — facts — without regard to how they go together. Brickmaking, Forscher feared, had become an end in itself. “And so it happened that the land became flooded with bricks. … It became difficult to find the proper bricks for a task because one had to hunt among so many. … It became difficult to complete a useful edifice because, as soon as the foundations were discernible, they were buried under an avalanche of random bricks.” [Note A]

The situation today, Weinberger argues, is astronomically - and I use the word “astronomically” quite deliberately, in the sense of “several orders of magnitude” - worse than it has ever been.  In an article introducing his book, he puts the problem thus:

There are three basic reasons scientific data has increased to the point that the brickyard metaphor now looks 19th century. First, the economics of deletion have changed. We used to throw out most of the photos we took with our pathetic old film cameras because, even though they were far more expensive to create than today’s digital images, photo albums were expensive, took up space, and required us to invest considerable time in deciding which photos would make the cut. Now, it’s often less expensive to store them all on our hard drive (or at some website) than it is to weed through them.

Second, the economics of sharing have changed. The Library of Congress has tens of millions of items in storage because physics makes it hard to display and preserve, much less to share, physical objects. The Internet makes it far easier to share what’s in our digital basements. When the datasets are so large that they become unwieldy even for the Internet, innovators are spurred to invent new forms of sharing.  The ability to access and share over the Net further enhances the new economics of deletion; data that otherwise would not have been worth storing have new potential value because people can find and share them.

Third, computers have become exponentially smarter. John Wilbanks, vice president for Science at Creative Commons (formerly called Science Commons), notes that “[i]t used to take a year to map a gene. Now you can do thirty thousand on your desktop computer in a day. [Note A]

The result, Weinberger argues, is actually worse than Forscher predicted.  We are not merely awash in “bricks/facts” and suffering from a severe shortage of “theory-edifices” to organize them with; the profusion of data has revealed to us systems of such massive intricacy and interdependence that we are incapable of visualizing, let alone formulating, comprehensive theories to reduce them to manageable - by which is meant, predictable - rules of behaviour.  Scientists facing “data galaxies” are being forced down one of two paths.  The first path - reductionism - attempts to derive overarching, general principles that seem to work well enough to account for the bulk of the data.  Historically, searching for “universals” amid the vast sea of “particulars” has been the preferred approach of empirical science, largely because there tend to be many fewer universals than there are particulars in the physical world, and also because if you know the universals - for example, Newton’s laws of motion and the fact that gravitational attraction between two objects varies inversely as the cube of the distance separating them - then you can often deduce the particulars, for example, where you should aim your Saturn V rocket in order to ensure that the command and service module achieves Lunar orbit instead of ending up headed for the heliopause.

The second path - modelling - involves the construction of tunable mathematical models that can be tweaked to produce outputs that mimic, as closely as possible, observational data without attempting to derive an overarching theory of how the system that produced the data actually functions.  This has been the preferred approach for dealing with complex phenomena that do not easily lend themselves to reduction to “universals”.  When it comes to complex systems, however, both paths exhibit crippling flaws.  Overarching theories that explain some data, but not all of it, can help us to approach a solution, but they cannot produce “settled science” because unexplained data are by definition the Achilles Heel of any scientific theory.  Meanwhile, modelling, even if it can come close to reproducing observed data, cannot replace observed data, and is never more than a simulation - often a grossly inaccurate one - of how the real world works, because if we cannot visualize all of the complexities and interdependencies of a given problem set, we certainly cannot design mathematical formulae to simulate them.

As if these two unacceptable paths were not bad enough, perhaps the most alarming deduction that Weinberger draws from his analysis is that these data-driven trends are forcing us towards a “new way of knowing” that is, from a human perspective, almost entirely “virtual.”  According to Weinberger, only computers can generate the vast quantities of data necessary to investigate a given phenomenon; only computers have the capacity to organize and store so much data; and only computers can perform the unthinkable number of calculations necessary to process the data and create modelled outputs.  Our role, such as it is, has been to create the mathematical models for the computers - but even this last redoubt of human involvement is collapsing as we become increasingly incapable of visualizing the scope and interrelationships of the problems we are trying to solve.  In other words, the future of research into complex interdependent phenomena is gradually departing the human domain, simply because we lack the cognitive wherewithal needed to cope with it.

Does this mean that scientific inquiry is doomed to leave the human sphere entirely?  Or that it’s destined to grind to a halt unless we can come up with an AI that mimics human cognition to the point of being able to visualize and craft investigative solutions to huge, complex problems?  I certainly don’t dispute that science has developed the ability to drown itself in data; but there are ways of dealing with preposterous quantities of information.  As I believe I’ve pointed out before, historians are accustomed to being drowned in data.  From the point of view of the science of historiography, this is not a new problem.  Take, for example, a relatively straightforward historical event - the Battle of Waterloo.  Working from basic numbers, Napoleon had about 72,000 troops, and the Allies under Wellington had about 118,000.  Reducing the affair to nothing more than a series of iterative diarchic interactions (which I am the first to admit is a wholly ludicrous proposition, but which frankly is no more ridiculously inappropriate than some of the assumptions made in climate modelling - for example, the assumption that clouds warm the Earth, when observed data suggest that they cool it) suggests that there were about 8.5 billion potential diarchic interactions in the first iteration alone.  And that’s only the individuals.  Nothing is too insignificant to be eliminated from your model, and each increase in the fidelity of the data you input ought to help refine the accuracy of your output (unless you’re trying to model a non-linear system, in which case the fidelity of your input doesn’t matter because inherent instabilities will quickly overwhelm the system (see “Nonlinearity andthe indispensability of data”, 15 June 2011)).  In the quest for greater fidelity/realism, you would need to model the characteristics and behaviour not just of each individual but also of their weapons, their clothing, their boots or shoes, their health and physical condition, their horses, their guns, their limbers, their ammunition, the terrain, the obstacles, the weather, the psychological vagaries of individual soldiers and commanders...how many details are we talking about here?  Are we getting to the level of a “non-visualizable” problem yet?

Is it even possible to model something this complex?  Well, it’s sort of already been done.  I’m sure many of you have seen The Lord of the Rings: The Two Towers.  The final battle at Helm’s Deep comprised hundreds of Rohirrim and Elves, and ten thousand Uruk-Hai - and yet there were no more than a hundred live actors in any of the shots.  The final digital effects were created by Weta Digital using a programme called “Massive”.  According to Stephen Regelous, the chap who programmed the battle sequences, he didn’t really “program” them at all, or at least, not in the sense of crafting specific movements for every digital effect in the scenes.  That would have been an impossibly daunting task, given the number of individual digital actors involved.

Instead, he made the digital actors into people.  “The most important thing about making realistic crowds”, Regelous explains, “is making realistic individuals.”  To do that, the programme creates “agents”, each of which is in essence an individual with individual characteristics, traits, and most important of all, volition:

In Massive, agents’ brains - which look like intricate flow charts - define how they see and hear, how fast they run and how slowly they die. For the films, stunt actors’ movements were recorded in the studio to enable the agents to wield weapons realistically, duck to avoid a sword, charge an enemy and fall off tower walls, flailing.

Like real people, agents’ body types, clothing and the weather influence their capabilities. Agents aren’t robots, though. Each makes subtle responses to its surroundings with fuzzy logic rather than yes-no, on-off decisions. And every agent has thousands of brain nodes, such as their combat setting, which has rules for their level of aggression. When an animator places agents into a simulation, they are released to do what they will. It’s not crowd control, but anarchy. Each agent makes decisions from its point of view. [Note B]

In other words, outcomes aren’t predetermined; the Agents are designed with a range of options built into their makeup, and a degree of choice about what to do in response to given stimuli.  Kind of like people.  While it’s possible to predict likely responses to certain stimuli, it’s not possible to be certain what a given Agent will do in response to a given event.  “It’s possible to rig fights, but it hasn’t been done,” Regelous says. “In the first test fight we had 1,000 silver guys and 1,000 golden guys. We set off the simulation, and in the distance you could see several guys running for the hills.”

If you happen to own the full-up Uber-GeekPathetic Basement-Dwelling Fan-Boy LOTR collection (I admit nothing!), you can watch the “Making Of” DVDs for Two Towers, and listen to a much more in-depth explanation of how chaotic, complex and unpredictable the behaviour of the Massive-generated battle sequences were.  The programmers ran the Helm’s Deep sequence many, many times, using the same starting conditions, and always getting different results.  If that sounds familiar, it’s because it’s exactly what Lorenz described as the behaviour of a non-linear system.  It’s chaos in a nutshell. 

According to the DVD explanation, the results of individual volition were potentially so unpredictable that the Agents’ artificial intelligence needed a little bit of tweaking to ensure that the battle scenes unfolded more or less in line with the script.  Early on, for example, the designers had given each Agent a very small probability of panicking and fleeing the battle, along with a slight increase to that probability if a neighbouring agent went down hard, and a slightly greater probability if a neighbouring agent panicked and fled.  Reasonable, right?  We all know that panic on the battlefield is contagious.  The problem is that, depending on how the traits of the Agents were programmed, it could be too contagious.  In one of the simulation runs for the battle, one of the Uruk-Hai Agents near the front lines apparently panicked and fled at exactly the same time as a couple of nearby Agents were shot and killed.  This sparked a massive, rapidly propagating wave of panic that resulted in Saruman’s elite, genetically-engineered army dropping their weapons and heading for the hills.  I’m sure King Theoden, Aragorn, and hundreds of unnamed horse-vikings and elf-archers would’ve preferred it if Jackson had used that particular model outcome for the film, but it probably wouldn’t have leant itself to dramatic tension. And it would've been something of a disappointement when Gandalf, Eomer and the Rohirrim showed up as dawn broke across the Riddermark on the fifth day, only to discover that there was no one left for them to fight because Uruk Spearman #9551 had gone wobbly a couple of hours before.

What’s the point of all this?  Well, the link between Forscher’s complaint about the profusion of data-bricks and Weinberger’s conclusion that computers are taking over the process of generating, storing, and figuring out what to make of data is obvious.  The problem of deriving “universals” from the colossal mass of “particulars” that make up modern scientific (and historical) inquiry ought to be obvious, too, and it’s demonstrated by one of the key weaknesses of history: experimental repeatability.  Steve Regelous could re-run the Battle of Helm’s Deep as many times as he liked until he got the result that Peter Jackson wanted - but that’s fiction, and when you’re writing fiction you can do whatever you like because you’re not tied to any objective standard other than some degree of plausibility (which in turn depends on the expectations, experience and gullibility of your audience).  But we can’t re-run the Battle of Waterloo, changing one variable here or there to see what might have happened differently, because there’s no way to account for all possible variables, there’s no way to find out whether some seemingly insignificant variable might have been overwhelmingly important (butterfly wings, or “for want of a nail”, and all that), and finally there’s no way to scientifically validate model outputs other than to compare them to observed data, because historical events are one-time things.

What we can do, though, is try to develop rules that help us winnow the “universals” from the chaff that makes up most of history.  There were 190,000 “Agents” at Waterloo - but do we really need to know everything about them, from their shoe size to how many were suffering from dysentery on the big day?  Do we need all of the details that had to be programmed into Weta’s “Massive” Agents?  Or are there some general principles that we can use to guide our understanding of history so that we can pull out what’s important from the gigantic heap of what isn’t?

This is where a good reading - or hopefully re-reading - of E.H. Carr’s What is History? comes in handy.  In Chapter One, “The Historian and His Facts”, Carr disputes the ages-old adage that “the facts speak for themselves”, arguing instead that the facts speak only when the historian calls on them.  Figuring out which facts to call on is the historian’s métier.  Separating the gold - the “significant” as opposed to the “accidental” facts of a given phenomenon - from the dross of historical data is the historian’s challenge, and Carr’s criteria for judgement of what is “gold” is generalizability.  The key word here, of course, is “judgement” - informed judgement as a function of human cognition.  This is something that can’t be done by computers. 
 
Not yet, anyway. [Notes C, D] 

So for the time being, at least, there’s still a need for a meat plug somewhere in the analysis chain, if only to provide the informed judgement that our eventual silicon replacements haven’t quite learned to mimic.  That’s something of a relief.

Cheers,

//Don// (Meat plug)

Notes:


C) Historians looking for a lesson in humility need only read Heinlein’s The Moon is a Harsh Mistress, in which a computer that accidentally becomes artificially intelligent finds itself having to run a Lunar uprising - and in order to design the best possible plan for doing so, reads every published history book in a matter of minutes, analyzes them, and then not only plots a revolution from soup to nuts, but actually calculates the odds of victory, and recalculates them periodically in response to changing events.  Now that’s what I call “future security analysis.”  If only.

D) Some computer programmes are getting pretty good at matching human cognition.  Fortunately, we still hold an edge in important areas.  As long as we can still beat our electronic overlords at “Rock-Paper-Scissors”, we might, as the following chart from the genius webcartoon xkcd.com suggests, be able to hold the Singularity off for a little longer.
 


Sunday, June 3, 2012

7 June 2011 – Royal blush

Colleagues,

Email being what it is, I found myself engaged in a series of exchanges yesterday that was launched when a certain colleague, who shall remain nameless, forwarded a copy of an article detailing a developing scandal in Sweden over allegations contained in a book published last year.  According to author Roger Lundgren, who penned The Reluctant Monarch, HM King Carl Gustav of Sweden frequented strip clubs in Slovakia and the US during travels in those countries.(Note A)  This initial article led to numerous observations about the pulchritudinal penchants of Europe’s throng of miscellaneous nobles, and how they all seem to evince similar proclivities for scandal.

HM King Carl XVI Gustav of Sweden.  I wish my folks had named me after an anti-tank weapon.

Leaving aside the incongruity of the Scandinavian press with its Side 9 Pigern (“Page 9 Girls”) expressing puritanical shock and dismay at such reprehensible conduct, it wasn’t the “scandal” so much as the “sameness” of it that got me thinking about the similarities between so many royals.  While I’m something of a monarchist, I’m the opposite of a royal-watcher, and I certainly don’t purport to be an expert on genealogy; and I don’t subscribe to Thomas Carlyle’s “great man” theory of history (or at least not to all of it).  But as I’ve said before, history by its very nature is comprised of people and the impact of their actions on the flux and flow of international events.  We ignore interconnectivity between people at our peril.  To put it another way, given how often we have to listen to folks ramble on about “complexity”, it’s worth remembering that one of the characteristics of complexity (and therefore of ”complex systems”, another phrase used ad nauseum these days) is interdependence between individual actors.  Ceteris paribus, the greater the number of “nodes” where two or more individual actors interact, the greater the level of actual or potential complexity in a given system.

We don’t have to look to the computing sciences or delve into the mysteries of bosons, mesons and other members of the subatomic bestiary for examples of this sort of thing.  History - the history of people and their interactions, especially when the inter-actors are people who exercise power and influence - provides a wealth of examples of complex systems.  This was brought forcibly to my attention when, during a visit to Denmark in 1990 to be vetted by my future in-laws, I visited Christiansborg Castle in Copenhagen and saw this painting:

 “Fredensborg Days”, Laurits Tuxen (painted 1863-1866)

The painting - which, at 5 x 7 metres, is bloody enormous - takes up a whole wall and depicts a fictionalized scene during the “Fredensborg Days” period of the monarchy of King Christian IX of Denmark (1818-1906), who was on the throne from 1863 until his death, making him one of the longer-reigning monarchs in Danish (and European) history.  The painting’s informal name is “The Father-In-Law of Europe” because of its depiction of the massive range of family connections enabled by Christian’s six children.  You can see Christian and his wife, Louise of Hesse-Kassel, seated on the blue settee.  There are a number of other notables in the painting; I’ll get to them in a few moments.

I won’t go into too much detail about how he ended up on the throne.  Suffice it to say that Christian, a scion of a lesser male branch of the ruling Oldenburg family, found himself at the centre of a succession debate resulting from the inability of King Frederick VII to father children.  Christian’s marriage to Louise proved to be fortuitous and an example of dynastic foresight; as a great-niece of Christian VII (b.1749, r.1766, d.1808) she actually had a better claim to the throne than her husband (save for the fact that Denmark adhered to a partial version of the Salic Law that prohibited - as Shakespeare put it in Henry V - “your highness claiming from the female”).  In 1847, the great powers of Europe put their heads together and nominated Christian to succeed Fredrick when the latter should shuffle off the mortal coil; Fredrick agreed in exchange for promises of financial support. 

When Fredrick died in November 1863 and Christian came to the throne, an immediate crisis exploded over possession and status of Fredrick’s hereditary domains of Schleswig and Holstein, two provinces on the Danish-Prussian border.  Christian signed the November Constitution, making Schleswig part of Denmark, and resulting in a brief war between Denmark and a Prussian/Austrian alliance in 1864.  While this Second War of Schleswig didn’t turn out well for Denmark (Schleswig and Holstein, along with Saxe-Laurenburg, became Prussian and Austrian possessions in 1865 under the Treaty of Vienna), it did include the famous Battle of Dybbøl Mølle, a defensive action outside of the southern Danish city of Sønderborg, which was notable for the use of complex defensive earthworks of a type that wouldn’t be seen again until 1914 (you can visit the site; the windmill - which is what mølle means - is still there).

“Kampene ved Dybbøl, 1864”, by Jørgen Valentin Sonne, 1871

It’s worth noting that the trench system constructed by the Danes at Dybbøl Mølle followed and was built on the line of the Danevirke, a system of fortifications more than a thousand years old, which had been begun by King Gudfred in 808 to defend against the Franks, recently united under Charlemagne.  There’s a reason that battles keep happening at strategic places; it’s called “geography”. 

Anyway, back to Christian IX.  His accession to the throne put an end to the Oldenburg Dynasty and launched the Glucksburg dynasty, only the second dynastic change in the history of Denmark’s royal family (the Oldenburgs came to the Danish throne with the election of Christian I in 1448, replacing the succession of Viking and Medieval kings that had preceded them since Gorm the Old, who reigned from 936-958 AD).  The number of kids that Christian and Louise managed to produce over the next several years (as well as Christian’s staunch defence of the prerogatives of the monarchy and his resistance to the liberalizing forces sweeping Europe in the latter half of the Victorian era) created complex familial nodes that continue to dominate Europe’s royal relations today.  His children, their spouses, and their grandchildren included:

·         King Fredrick VIII of Denmark (1843-1912) m. Princess Lovisa of Sweden

o   King Christian X of Denmark

o   King Haakon VII of Norway

o   Princess Louise of Denmark

o   Prince Harald of Denmark

o   Princess Ingeborg of Denmark

o   Princess Thyra of Denmark

o   Prince Gustav of Denmark

o   Princess Dagmar of Denmark

·         Princess Alexandra of Denmark m. King Edward VII of the UK

o   Prince Albert Victor, Duke of Clarence

o   King George V

o   Louise, Princess Royal

o   Princess Victoria

o   Prince Maud of Wales

o   Prince Alexander John of Wales

·         King George I of Greece m. Olga Konstantinovna of Russia

o   King Constantine I of Greece

o   Prince George of Greece and Denmark

o   Princess Alexandra of Greece and Denmark

o   Prince Nicholas of Greece and Denmark

o   Princess Maria of Greece and Denmark

o   Princess Olga of Greece and Denmark

o   Prince Andrew of Greece and Denmark

o   Prince Christopher of Greece and Denmark

·         Dagmar of Denmark m. Czar Alexander III of Russia

o   Czar Nicholas II of Russia

o   Grand Duke Alexander Alexandrovich

o   Grand Duke George Alexandrovich

o   Grand Duchess Xenia Alexandrovna

o   Grand Duke Michael Alexandrovich

o   Grand Duchess Olga Alexandrovna

·         Thyra of Denmark m. Ernst August of Hanover, 3rd Duke of Cumberland

o   Princess Marie Louise of Hanover and Cumberland

o   Prince George William of Hanover and Cumberland

o   Princess Alexandra of Hanover and Cumberland

o   Princess Olga of Hanover and Cumberland

o   Prince Christian of Hanover and Cumberland

o   Prince Ernest Augustus of Hanover, Duke of Brunswick

·         Prince Valdemar of Denmark m. Marie of Orléans

o   Prince Aage of Denmark

o   Prince Axel of Denmark

o   Prince Erik of Denmark

o   Prince Viggo of Denmark

o   Princess Margaret of Denmark

Say what you like, that’s a perfectly astonishing brood.  And there are some pretty big names among Christian’s list of grand-kids.  If you take a swing around Europe’s royal families these days, quite a few of them still have a Viking somewhere in the woodpile.  Let’s try it out, starting with an easy one:

·         Margrethe II of Denmark: Fredrick IX - Christian X - Fredrick VIII - Christian IX of Denmark

·         Elizabeth II of the United Kingdom: George VI - George V - Princess Alexandra of Denmark - Christian IX of Denmark

·         Harald V of Norway: Olav V - Haakon VII - Frederick VIII of Denmark - Christian IX of Denmark

·         Albert II of Belgium: Astrid of Sweden - Princess Ingeborg of Denmark - Fredrick VIII of Denmark - Christian IX of Denmark

·         Constantine II of Greece (until the monarchy was abolished in 1973): Paul of Greece - Constantine I - George I - Christian IX of Denmark

Queen Beatrix of the Netherlands, Prince Henri of France, Grand Duke Henri of Luxembourg, Nicholas Romanov of Russia, and Hans-Adam II of Lichtenstein are not directly descended from Christian IX, putting them in something of a minority (especially as the French and Russian royal houses are considered ‘deposed’).  And while King Juan Carlos of Spain is not descended from Christian, his son and heir-apparent, Felipe Prince of Asturias, is, by virtue of Juan’s marriage to Sophia of Greece and Denmark (eldest child of Paul of Greece, and sister to King Constantine II of Greece) another descendent of Christian IX.  So once Juan Carlos disappears into the pages of history, the next King of Spain will be one Christian IX’s scions, further cementing that ancient gentleman’s hold on the thrones of Europe.

And what of our friend Carl XVI Gustav, whose indiscretions launched this whole line of discussion?  Well, it turns out that, unlike so many of his peers, he is not in fact, a descendent of Christian IX. 

Charles Edward, Duke of Saxe-Coburg and Gotha, Grandfather of King Carl Gustav, ca. 1933

But he came close.  Carl is the son of Princess Sibylla of Saxe-Coburg and Gotha, who was the daughter of Charles Edward, Duke of Saxe-Coburg and Gotha - a chap infamous in the Swedish royal lineage for having been an Obergruppenfuhrer of the S.A.  Charles Edward was something of a scandal for the British royal family too.  He was the eldest (and only) son of Prince Leopold, Duke of Albany, who was the eighth child and fourth son of Victoria and Albert. 

 Prince Leopold, Duke of Albany (1853-1884)

Prince Leopold, a haemophiliac, was notoriously frail and, as such, his mother (protective at the best of times) did her best to keep him around the house.  Seeing marriage as his only chance for escape, Leopold expressed an interest in a number of prominent ladies of the era - including, interestingly, Alice Liddel, the daughter of the vice-chancellor of Oxford for whom Reverend Dodgson (aka Lewis Carrol) wrote Alice’s Adventures in Wonderland.  Leopold eventually married (at his mother’s suggestion, natch) Princess Helene Friederieke, the daughter of Georg Viktor, Prince of Waldeck-Pyrmont, in 1882.  But before he did, he courted none other than Princess Karoline Mathilde of Schleswig-Holstein-Sonderburg-Augustenburg, a great-niece of Victoria, and a daughter of one of Napoleon III’s paramours and Fredrick VIII, Duke of Schleswig Holstein.  Fred was the rival Oldenburg claimant to the duchies that were at stake when Christian IX took the Danish throne for the Glucksburgs in 1863, and later lost to Prussia and Austria.  Had his great-grandfather Leopold married Princess Karoline, Carl Gustav would’ve enjoyed an older (and Salic Law-compliant) claim to the Danish throne than its current occupant, Margrethe II. 

History is full of what-ifs.  For one of the best examples imaginable, take another look at that painting of Christian IX and his flock of relatives.  Two of the children depicted are the future King George V of the UK and the future Czar Nicholas II of Russia (probably added as the painting was being completed, seeing as how they were born, respectively, in 1865 and 1868). 

Here’s what Nick (on the left) and George (on the right) looked like forty years later, in 1913:


The resemblance is uncanny, and it goes beyond the mere physical.  Reigning monarchs, first cousins, and virtual twins, glorious in their finery - blissfully unaware that the world they knew would cease to exist in less than a year, and that only three years after that, the gentleman on the left, with all of his family, would be butchered by Bolshevik fanatics in a filthy basement in Yekaterinburg.

One line dies, another line lives on.  There’s something to be said for having big families - even if, from time to time, some of them get up to shenanigans.

Cheers,

//Don//

P.S.      If you like big-scene paintings, here’s another one by Tuxen - the wedding of Nicholas II in 1895: http://en.wikipedia.org/wiki/File:TsarNicholasIIWedding.jpg
P.P.S.   Tuxen’s also famous for being a member of the “Skagen School” of artists that painted realistic maritime scenes of the northernmost tip of Denmark.  I have a number of prints (my wife’s maternal grandfather was a merchant marine/fisherman).  Here’s an example of that sort of work: http://rubensgallery.org/upload1/file-admin/images/new22/Laurits%20Tuxen-227734.jpg

Notes
A) [http://www.smh.com.au/lifestyle/people/strip-club-scandal-pressure-mounts-on-swedish-king-20110607-1fpty.html].

Saturday, March 17, 2012

2 September 2010 – The Men Who Genetically Engineer Goats

Colleagues,

It might just be my imagination, but for some reason, butyrylcholinesterase seems to be popping up in the news a lot these days.


Butyrylcholinesterase - or, as it’s more commonly known, BChE, or serum cholinesterase - is a complex enzyme that occurs naturally in human blood, and is structurally rather similar to acetylcholinesterase, or AChE.  That latter enzyme probably sounds more familiar to you.  This is because it is the enzyme that is bound (i.e., deactivated) by exposure to organophosphorous compounds, such as the G and V nerve agents (note 1).  Simply put, the transmission of electrical messages between axons and dendrites of nerve cells is effected by acetylcholine, which is subsequently dismantled into its acetyl and choline groups by AChE.  Inhibition of AChE leads to what amounts to continuous firing of nerves, resulting in symptoms ranging from pupillary dilation, excessive salivation and production of mucous, and shortness of breath, to convulsions, cardiac arrest and death, usually through suffocation due to paralysis of the diaphragm.